Table 2.

Anticancer activities [IC₅₀ (µM) ± SD] of GDM and its 1 and 8 analogues and salts (9–13) in SKBR-3, SKOV-3, PC-3, U-87, A-549 cells (2nd panel), and toxicity in human dermal fibroblasts (HDF) cell line [IC₅₀ (µM) ± SD] together with selectivity indexes [SI_HDF].

Cmpd.	SKBR-3	SKOV-3	PC-3	U-87	A-549	HDF
GDM	0.87 ± 0.17 [SI 2.45]	0.94 ± 0.09 [SI 2.27]	0.73 ± 0.01 [SI 2.92]	0.81 ± 0.12 [SI 2.62]	0.99 ± 0.01 [SI 2.15]	2.13 ± 0.11
1	7.44 ± 0.09 [SI 4.03]	8.04 ± 0.24 [SI 3.73]	7.02 ± 0.06 [SI 4.28]	7.32 ± 0.49 [SI 4.10]	9.01 ± 0.63 [SI 3.33]	30.02 ± 1.03
8	1.49 ± 0.29 [SI 2.16]	1.16 ± 0.92 [SI 2.78]	1.47 ± 0.31 [SI 2.19]	1.08 ± 0.16 [SI 3.43]	0.94 ± 0.03 [SI 3.43]	3.22 ± 0.18
9	3.12 ± 0.01 [SI 1.70]	3.86 ± 0.05 [SI 1.37]	3.01 ± 0.11 [SI 1.76]	3.69 ± 0.08 [SI 1.43]	3.09 ± 0.01 [SI 1.71]	5.29 ± 0.17
10	1.94 ± 0.52 [SI 1.53]	1.61 ± 0.13 [SI 1.84]	1.88 ± 0.02 [SI 1.57]	1.84 ± 0.11 [SI 1.61]	1.29 ± 0.07 [SI 2.29]	2.96 ± 0.36
11	6.49 ± 0.07 [SI 1.22]	6.04 ± 0.38 [SI 1.31]	6.22 ± 0.13 [SI 1.27]	6.06 ± 0.58 [SI 1.31]	6.83 ± 0.32 [SI 1.16]	7.91 ± 0.91
12	8.49 ± 0.36 [SI 1.64]	8.02 ± 0.17 [SI 1.73]	7.94 ± 0.03 [SI 1.75]	8.58 ± 0.19 [SI 1.62]	8.94 ± 0.27 [SI 1.56]	13.91 ± 0.42
13	2.02 ± 0.11 [SI 1.89]	2.17 ± 0.06 [SI 1.76]	2.05 ± 0.09 [SI 1.86]	2.26 ± 0.15 [SI 1.67]	2.06 ± 0.01 [SI 1.85]	3.81 ± 0.11

Selectivity index [SI_HDF] = IC₅₀ normal cell line HDF/IC₅₀ respective cancer cell line.