Table 3.
α-Amylase and DPP-4 inhibitory activities of M. latifolia fractions and isolated compounds.
| IC50 (μg/mL) |
||
|---|---|---|
| α-Amylase | DPP-4 | |
| Fractions | ||
| CF1 | 954.63 ± 32.09h | 581.50 ± 12.77d |
| CF2 | 1025.41 ± 218.64i | 80.40 ± 6.84b |
| CF3 | 397.68 ± 10.41f | 37.16 ± 3.02a |
| CF4 | 831.72 ± 9.25g | 160.00 ± 15.21c |
| Compounds | ||
| 1 | 154.4 ± 15.80 (372.31 ± 2.62 μM)c | ND |
| 2 | 54.53 ± 3.19 (197.53 ± 4.18 μM)a | ND |
| 3 | 220.60 ± 9.11 (1238.90 ± 22.05 μM)e | 162.40 ± 1.45 (911.44 ± 7.61 μM)c |
| 4 | 89.31 ± 11.30 (579.94 ± 3.18 μM)b | ND |
| Sitagliptin | – | 0.014 ± 0.01 (0.034 ± 0.04 μM)f |
| Acarbose | 182.31 ± 20.16 (282.39 ± 8.14 μM)d | – |
ND: not determined where IC50 was not detected at highest tested concentration (1 mg/mL). ‘–’: Not available. All values were expressed as mean ± standard deviation of triplicates. Data with different superscript (a, b, c, d, e, f, g, h, i) in the same column were considered significant (p < 0.05).