Table 5.

The calculated ΔG (binding free energies) of the synthesised compounds and reference drug against VEGFR-2 (PDB ID; 2OH4 and 4ASD) (ΔG in Kcal/mole).

Comp.	VEGFR-2 (PDB ID: 2OH4) ΔG [Kcal/mole]	VEGFR-2 (PDB ID: 4ASD) ΔG [Kcal/mole]
27a	−25.71	−28.56
27b	−25.45	−25.51
27c	−10.82	−11.23
27d	−14.22	−20.33
27e	−23.61	−22.41
27f	−20.71	−21.06
28	−26.41	−29.46
29	−23.48	−25.22
30a	−16.47	−22.47
30b	−17.08	−23.62
30c	−21.59	−28.38
30d	−27.45	−24.17
30e	−20.74	−19.11
30f	−23.22	−16.83
30g	−18.23	−25.34
30h	−24.05	−20.07
30i	−20.62	−27.93
31a	−26.77	−29.15
31b	−25.01	−23.61
32	−21.66	−23.49
Sorafenib	−30.07	−36.05