Table 2.

Summary of data extraction

Study identification	Study first author; article title; journal title; publication year; study type (discovery and/or validation; diagnostic and/or prognostic);
Cohort identification and methodology	Cohort first author; journal title; publication year; GEO and/or ArrayExpress database; country or geographic region of the study; cohort type (discovery, test or validation); study design (cross-sectional, case-control, prospective cohort, randomised control trial or other); study setting; age groups of participants (child, adolescent, adult or mixed); sample size; sampling method and participant selection (consecutive, convenience, random, other); sample representative of target population (were participants with suspected but unconfirmed tuberculosis excluded introducing spectrum bias); control group definition (LTBI, healthy control and/or other disease); microbiological reference standard(s) used to diagnose tuberculosis disease; clinical and/or composite non-microbiological methods of tuberculosis diagnosis; method of LTBI diagnosis (TST >5 mm, TST >10 mm, IGRA: T-Spot.TB or QuantiFERON); duration of follow-up for prediction of progression to incident tuberculosis; signature measurement method (RNA sequencing, microarray, PCR or other) and sample type (whole blood or PBMC); flow and timing of index and reference test measurement; study blinding
Signature characteristics	Signature discovery author; publication year; country or geographical region of discovery cohort; study design; signature discovery method (RNA sequencing, microarray, PCR or other) and sample type (whole blood or PBMC); transcripts included in the signature; signature model; intended use of signature.
Outcome data	True and false positives; true and false negatives; sensitivity; specificity; area under the curve; signature positivity rate (prevalence) in study population; signature cut-off/threshold applied (if reported); 95% CI for all estimates.

GEO, gene expression omnibus; IGRA, interferon-gamma release assay; LTBI, latent tuberculosis infection; PBMC, peripheral blood mononuclear cells; RNA, ribonucleic acid; TST, tuberculin skin test.