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. 2021 Jun 25;3(4):e200069. doi: 10.1148/rycan.2021200069

Figure 1:

(A) A schema shows the main structural elements of F(ab’)2 conjugates with deglycosylated horseradish peroxidase (HRP) and glucose oxidase (GOx) synthesized by using metal-free click chemistry. (B) A schema of enzymatic activity complementation involving reaction between GOx conjugated to F(ab’)2 and glucose that provides hydrogen peroxide used by HRP in the presence of 5-hydroxytryptamide of 2,2′,2′′-(10-(2,6-dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid-chelated gadolinium (III) or gallium 68 (68Ga) (III).

(A) A schema shows the main structural elements of F(ab’)2 conjugates with deglycosylated horseradish peroxidase (HRP) and glucose oxidase (GOx) synthesized by using metal-free click chemistry. (B) A schema of enzymatic activity complementation involving reaction between GOx conjugated to F(ab’)2 and glucose that provides hydrogen peroxide used by HRP in the presence of 5-hydroxytryptamide of 2,2′,2′′-(10-(2,6-dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid-chelated gadolinium (III) or gallium 68 (68Ga) (III).