Table 1.
Failure pressures (mean ± SEM) for the thoracic aorta from WT and Thbs2−/− groups at 20 and 40 weeks of age.
| 20 weeks | 40 weeks | |||
|---|---|---|---|---|
| WT | Thbs2−/− | WT | Thbs2−/− | |
| n | 5 | 8 | 6 | 5 |
| Burst Pressure (mmHg) | 1120 ± 45 | 640 ± 37* | 1048 ± 110 | - |
| Delamination Pressure (mmHg) | - | 549 ± 61 | 585 | 415 ± 33 |
*
p < 0.05 compared to age-matched WT mice (genotype effect)
For comparison purposes, previously reported rupture pressures in common carotid arteries are 1644 ± 54 mmHg for 6–9 month old (Louis et al., 2007) and 2100 ± 80 mmHg for 3 month old (Lacolley et al., 2001) control mice.