Figure 2.

Angiotensin-converting enzyme 2 (ACE2) expression does not vary by fetal sex or maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) status. A, ACE2 gene expression by fetal sex and maternal SARS-CoV-2 infection, relative to female negative controls, demonstrating no significant differences between groups. All expression levels are relative to reference gene YWHAZ. B, No significant differences were observed in ACE2 protein expression by Western blot analysis. Data analyzed by 2-way analysis of variance with Bonferroni post hoc testing. C, Representative Western blots showing ACE2 expression between males and females from pregnancies with and without exposure to maternal SARS-CoV-2 infection.