Table 2.
Demographic and Clinical Characteristics of Pregnancy Cohort by Fetal Sex and Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Status
| Female | Male | |||||
|---|---|---|---|---|---|---|
| Characteristic | All (N = 68) | SARS-CoV-2 Negative (n = 15) | SARS-CoV-2 Positive (n = 19)a | SARS-CoV-2 Negative (n = 15) | SARS-CoV-2 Positive (n = 19)a | P Valueb |
| Maternal age, y, median (IQR) | 33 (28–38) | 33 (30–36) | 34 (30–40) | 30 (27–37) | 31 (26–36) | .34 |
| Parity, median (IQR) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 1 (0–2) | .34 |
| Race | .19 | |||||
| White | 40 (59) | 11 (73) | 8 (42) | 12 (80) | 9 (59) | |
| Black | 5 (7) | 1 (7) | 3 (16) | 0 (0) | 1 (7) | |
| Asian | 1 (1) | 0 (0) | 0 (0) | 1 (7) | 0 (0) | |
| Other | 12 (18) | 3 (20) | 4 (21) | 1 (7) | 4 (8) | |
| Not reported | 10 (15) | 0 (0) | 4 (21) | 1 (7) | 5 (15) | |
| Ethnicity | .01 | |||||
| Hispanic | 32 (47) | 4 (27) | 11 (58) | 2 (13) | 15 (79) | |
| Non-Hispanic | 33 (48) | 10 (67) | 7 (37) | 12 (80) | 4 (21) | |
| Not reported | 3 (4) | 1 (7) | 1 (5) | 1 (7) | 0 (0) | |
| Hypertensionc | 8 (12) | 1 (7) | 1 (5) | 2 (13) | 4 (21) | .43 |
| Diabetesd | 6 (9) | 1 (7) | 3 (16) | 1 (7) | 1 (5) | .67 |
| BMI ≥30 kg/m2 | 20 (29) | 2 (13) | 7 (37) | 3 (20) | 8 (42) | .21 |
| Prepregnancy BMI, kg/m2, median (IQR) | 27.4 (21.5–30.8) | 25.8 (21.6–29.4) | 28.5 (26.5–32.7) | 21.5 (20.3–29.8) | 29.5 (22.3–32.0) | .06 |
| GA at delivery, completed weeks, median (IQR) | 39 (38–40) | 39 (39–39) | 39 (38–40) | 39 (39–41) | 39 (35–40) | .57 |
| Any labor | 52 (76) | 8 (53) | 16 (84) | 11 (73) | 17 (89) | .07 |
| Neonatal birthweight, g, median (IQR) | 3283 (3005–3590) | 3400 (3060–3590) | 3255 (2920–3340) | 3435 (3260–3730) | 3115 (2615–3590) | .06 |
| GA at positive SARS-CoV-2 test, completed weeks, median (IQR) | 36 (32–39) | NA | 36 (32–39) | NA | 35 (32–39) | .83 |
| COVID-19 disease severitye | .82 | |||||
| Asymptomatic | 16 (42) | NA | 8 (42) | NA | 8 (42) | |
| Mild/moderate | 19 (50) | NA | 9 (47) | NA | 10 (53) | |
| Severe/critical | 3 (8) | NA | 2 (11) | NA | 1 (5) | |
| Time between SARS-CoV-2 symptom onset and delivery, days, median (IQR) | 37 (18–57) | NA | 44 (28–64) | NA | 32 (8–51) | .18 |
Data are presented as No. (%) unless otherwise indicated.
Abbreviations: BMI, body mass index; COVID-19, coronavirus disease 2019; GA, gestational age; IQR, interquartile range; NA, not applicable; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
a”SARS-CoV-2 positive” indicates positive test for SARS-CoV-2 by nasopharyngeal real-time polymerase chain reaction during pregnancy.
bSignificant differences between groups were determined using χ 2 test for categorical variables and Kruskal–Wallis test for continuous variables.
c“Hypertension” indicates chronic or pregnancy-associated hypertension.
d“Diabetes” indicates preexisting or gestational diabetes.
eSeverity determinations were made at the time of diagnosis and based on published criteria from the National Institutes of Health.