Table 3.

Univariate and multivariable Cox regression model for in-hospital death

		Univariable		Multivariable
	Level/units	HR (95% CI)	P-value	HR (95% CI)	P-value
Clinical characteristics
Age	+5 years	1.06 (1.05–1.08)	<0.001	1.28 (1.14–1.43)	<0.001
Gender	Male vs. female	1.32 (0.92–1.90)	0.125	2.12 (1.26–3.56)	0.005
Heart failure	Yes vs. no	2.44 (1.70–3.52)	<0.001	1.78 (1.05–3.03)	0.033
Hypertension	Yes vs. no	1.91 (1.37–2.67)	<0.001	1.01 (0.64–1.60)	0.96
Atrial fibrillation	Yes vs. no	2.47 (1.73–3.53)	<0.001	1.73 (1.06–2.84)	0.029
Ischaemic cardiomyopahty	Yes vs. no	2.28 (1.65–3.16)	<0.001	1.02 (0.63–1.66)	0.922
Treatment before hospitalization
Anticoagulation therapy	Yes vs. no	1.43 (0.94–2.17)	0.091	0.73 (0.43–1.24)	0.250
Baseline findings
Oxygen saturation	+5%	0.96 (0.95–0.98)	<0.001	0.96 (0.94–0.98)	<0.001
Laboratory measurements
Red blood cell count	+1 ×106/µL	0.68 (0.54–0.86)	0.001	0.51 (0.28–0.92)	0.025
Haemoglobin	+1 g/dL	0.92 (0.85–0.98)	0.018	1.15 (0.94–1.41)	0.183
eGFR (CKD-EPI)	+10 mL/min	1.13 (1.05–1.21)	0.001	0.99 (0.99–1.00)	0.280
CRP peak	+1 mg/dL	1.00 (1.00–1.00)	<0.001	1.37 (1.09–1.72)	0.007
Troponin	Elevated vs. normal	3.19 (2.24–4.55)	<0.001	1.58 (1.02–2.45)	0.040

CKD-EPI, chronic kidney disease epidemiology collaboration formula; CRP, C reactive protein; eGFR, estimated glomerular filtration rate.