Table 2.
Summary of immunohistochemical and FISH studies
| Case | IHC profile of myoepithelial cells | IHC profile of duct-like component | FISH |
|---|---|---|---|
| 1 | Pos: CK7, p63, SMA, S100, SOX10, PLAG1 | Pos: CK7, TTF-1, Napsin A (PLAG1-negative) | PLAG1+ |
| 2 | Pos: AE1/AE3, p40, calponin, S100, SMA (focal) Neg: PLAG1 |
Pos: AE1/AE3, TTF-1, focally for mucicarmine | EWSR1−, FUS− |
| 3 | Pos: S100, SMA, calponin | Pos: EMA, CK7, TTF-1 | |
| 4 | Pos: AE1/AE3, p63 | Pos: AE1/AE3, TTF-1 | |
| 5 | Pos: p40, calponin, S100, SMA | Pos: CAM5.2, CK7, TTF-1 | MAML2−, CRTC1−, HMGA2−, PLAG1−, EWSR1−, and FUS− |
| 6 | Pos: : AE1/AE3, p63, S100, CK5/6, actin | Pos: CAM5.2, CK7, TTF-1 | |
| 7 | Pos: p63, weakly positive to negative AE1:AE3 | Pos: AE1/AE3, TTF-1, Napsin A |
SMA: smooth muscle actin