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. 2021 Jul 13;225(3):443–452. doi: 10.1093/infdis/jiab365

Figure 5.

Figure 5.

Cytomegalovirus (CMV)-associated age acceleration. The age acceleration due to CMV infection was determined by calculating the difference in the experimental epigenetic age (EpiAge) and predicted EpiAge. The predicted EpiAge was generated from a linear model based on the control CMV-negative group. A and B, The predicted and actual EpiAges were plotted against chronological age for CMV-negative and CMV-positive populations, and simple linear regressions were generated to visualize the relationship. C, Age acceleration was calculated for both CMV-negative (n = 21) and CMV-positive (n = 54) groups by calculating the difference between the predicted and actual EpiAges. The violin plot shows the frequency distribution of the data with a large dashed line at the median, small dashed line at the quartiles. Each dot represents an individual EpiAge. P values below .05 were considered significant.