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Non-compartmental analysis parameters for the anti-IL13Rα2 Ab at 1, 3, and 10 mg/kg
| Dose (mg/kg) | t½ (h) |
AUC (h.µg/mL) |
Cl (mL/h/kg) |
|
|---|---|---|---|---|
| Anti-IL13Rα2-Ab-AF680 | 1 | 80 | 663 | 1.34 |
| Anti-IL13Rα2-Ab-AF680 | 3 | 63 | 1924 | 1.46 |
| Anti-IL13Rα2-Ab-AF680 | 10 | 125 | 10,462 | 0.71 |
The PK parameters were determined from plasma concentrations of anti-IL13Rα2-Ab-AF680 at different timepoints obtained at three dose levels: 1, 3, and 10 mg/kg. Non-compartmental analysis was performed using software WinNonlin®.
