Figure 3.

KLF2 is a direct target of miR-15b-3p. (a) Differential analysis results of mRNAs in TCGA-UCEC (red for differentially upregulated mRNA and green for differentially downregulated mRNA); (b)Venn diagram of predicted targets and down-regulated mRNAs of miR-15b-3p; (c) The box plots of KLF2 expression in para-cancerous (gray) and cancer tissue (red); (d) Survival curves of patients with high KLF2 expression (red) and low KLF2 expression (blue); (e) Pearson correlation analysis on miR-15b-3p and KLF2; (f) qRT-PCR measured effect of miR-15b-3p on KLF2 mRNA expression; (g) Western blot measured effect of miR-15b-3p on KLF2 protein expression; (h) The targeted binding relationship between miR-15b-3p and KLF2 was detected by dual luciferase assay. * P < 0.05