Table 6.
Laboratory parameters for severe disease in children infected with SARS-CoV-2
| Parameter | Asymptomatic/mildly symptomatica (N = 363) | Moderate to severea (N = 39) | p-value |
|---|---|---|---|
| Haemoglobin, g/dl, mean ± SD | 11.3 ± 2.8 (N = 241) | 10.6 ± 3.2 (N = 27) | 0.263 |
| TLC/cm2, median (IQR) | 7731 (5120–11 900) (N = 236) | 10 970 (9100–18 600) (N = 26) | <0.001 |
| Lymphocyte %, median (IQR) | 33 (24–46.5) (N = 171) | 19.5 (12–41) (N = 25) | 0.024 |
| Platelet counts/cm2, median (IQR) | 267 000 (170 000–340 000) (N = 237) | 150 000 (79 000–268 000) (N = 26) | 0.032 |
| Urea, mg/dl, median (IQR) | 20 (16–27) (N = 236) | 29.5 (21–49) (N = 34) | <0.001 |
| Creatinine, mg/dl, median (IQR) | 0.5 (0.4–0.6) (N = 174) | 0.51 (0.4–0.9) (N = 34) | 0.145 |
| Sodium, mEq/l, mean ± SD | 136.9 ± 4.7. (N = 111) | 134.7 ± 6.9 | 0.046 |
| Total bilirubin, mg/dl, median (IQR) | 0.6 (0.37–0.8) (N = 163) | 0.62 (0.31–1.38) (N = 33) | 0.292 |
| SGOT, IU/l, median (IQR) | 33 (24–44) (N = 145) | 40.5 (28.0–87) (N = 24) | 0.042 |
| SGPT, IU/l, median (IQR) | 23.6 (16–34) (N = 148) | 28 (18–69) (N = 25) | 0.132 |
| Total serum protein, g/dl, mean ± SD | 6.6 ± 0.9 (N = 150) | 5.3 ± 1.2 (N = 23) | <0.001 |
| Serum albumin, g/dl, mean ± SD | 3.7 ± 0.8 (N = 152) | 2.8 ± 0.8 (N = 25) | <0.001 |
| Ferritin, ng/ml, median (IQR) | 132 (80.1–196) (N = 77) | 397.9 (148–879.2) (N = 18) | 0.002 |
| C-reactive protein, mg/dl median (IQR) | 0.52 (0.45–12) (N = 106) | 4.6 (1.4–30.4) (N = 17) | 0.005 |
| PCT, ng/dl, median (IQR) | 0.3 (0.02–0.5) (N = 72) | 0.8 (0.5–1.5) (N = 14) | <0.001 |
| PT, s, median (IQR) | 13.8 (12.8–15) (N = 38) | 16.7 (13–20.5) (N = 15) | 0.035 |
| INR, median (IQR) | 1.1 (1.0–1.2) (N = 36) | 1.2 (1.1–1.5) (N = 13) | 0.107 |
| aPTT, s, median (IQR) | 30 (27–32.2) (N = 35) | 34.1 (31.6–53.1) (N = 13) | 0.012 |
| LDH, median (IQR) | 233 (185.5–299.5) (N = 52) | 291 (228–531) (N = 11) | 0.037 |
| D-dimer, µg/ml, median (IQR) | 0.3 (0.28–0.44) (N = 64) | 0.34 (0.3–1.1) (N = 9) | 0.435 |
| IL-6, pg/ml | 21.8 (7.7–103.9) (N = 38) | 59.7 (10.2–108.8) (N = 12) | 0.733 |
TLC, total leucocyte counts; SGOT, serum glutamic-oxalacetic transaminase; SGPT, serum glutamic-pyruvic transaminase; PCT, procalcitonin; PT, prothrombin time; INR, international normalized ratio; aPTT, activated partial thromboplastin time; LDH, lactase dehydrogenase; IL-6, interleukin-6.
a
In the second and third column, N indicates the number of children for which particular data are available. Bold p-value indicates significant p-value