Table 7.
Logistic regression of features associated with moderate-severe disease in children with SARS-CoV-2
| Risk factor | Coefficient (95% CI) | Odds ratio (95% CI) | p-value |
|---|---|---|---|
| Fever | 1.47 (1.20 to 1.73) | 4.36 (3.33–5.67) | <0.001 |
| Rash | 1.85 (1.49 to 2.21) | 6.39 (4.48–9.13) | <0.001 |
| Diarrhoea | 0.22 (−0.26 to 0.69) | 1.24 (0.77–2.00) | 0.367 |
| Vomiting | 1.74 (1.42 to 2.06) | 5.74 (4.17–7.92) | <0.001 |
| Underlying illness | 2.18 (1.80 to 2.56) | 8.85 (6.07–12.91) | <0.001 |
| TLCa | 0.20 (0.08 to 0.31) | 1.21 (1.08–1.37) | 0.001 |
| Lymphocyte %a | 0.02 (−0.08 to 0.13) | 1.02 (0.92–1.14) | 0.670 |
| Platelet counta | −0.06 (−0.18 to 0.05) | 0.94 (0.83–1.05) | 0.270 |
| Urea | 0.03 (0.02 to 0.04) | 1.03 (1.02–1.04) | <0.001 |
| Sodium | −0.02 (−0.04 to 0.01) | 0.98 (0.96–1.01) | 0.134 |
| SGOTa | −0.02 (−0.17 to 0.13) | 0.98 (0.84–1.15) | 0.814 |
| Total protein | −0.45 (−0.65 to −0.26) | 0.64 (0.52–0.77) | <0.001 |
| Albumin | 0.13 (−0.12 to 0.37) | 1.14 (0.89–1.45) | 0.283 |
| Ferritina | 0.16 (−0.01 to 0.32) | 1.17 (0.99–1.38) | 0.057 |
| C-reactive proteina | 0.17 (0.01 to 0.33) | 1.19 (1.01–1.39) | 0.033 |
| PCTa | 0.05 (−0.06 to 0.15) | 1.05 (0.94–1.17) | 0.390 |
| PTa | −0.20 (−0.79 to 0.38) | 0.81 (0.45–1.47) | 0.499 |
| aPTTa | 0.57 (−0.03 to 1.17) | 1.76 (0.97–3.22) | 0.062 |
| LDHa | −0.20 (−0.33 to −0.07) | 0.81 (0.72–0.93) | 0.003 |
TLC, total leucocyte counts; SGOT, serum glutamic-oxalacetic transaminase; PCT, procalcitonin; PT, prothrombin time; aPTT, activated partial thromboplastin time; LDH, lactase dehydrogenase.
a
We used standardized z-score for these parameters as there were multiple zeroes after decimal. Bold p-value indicates significant p-value