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. 2021 Jul 22;12:706251. doi: 10.3389/fphar.2021.706251

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Copyright © 2021 Qi, Wang, Liao, Xue and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the effects of neferine on sepsis-induced myocardial dysfunction. Neferine suppressed LPS-induced cells apoptosis by regulating the PI3K/AKT/mTOR signaling pathway, which attenuates oxidative damage.