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. 2021 Feb 25;2:647134. doi: 10.3389/falgy.2021.647134

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Copyright © 2021 Walker, Ferrie, Hoji, Schroeder-Carter, Cohen, Schnaar and Cook-Mills.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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β-monohexosyl ceramides are increased in maternal and fetal tissues of allergic moms. Allergic moms were generated as in the timeline in Figure 1A. Tissue β-monohexosyl ceramides were measured by mass spectrometry in (A) mom plasma, (B) mom liver, (C) placenta, and (D) fetal liver on gestational day 18 of OVA-treated and saline-treated mothers. (E) Lipidomics bubble plot of fold change and significantly greater in OVA than saline treated groups for β-monohexosyl ceramides, ceramides, and sphingomylins. β-monohexosyl ceramides include both β-glucosyl and β-galactosyl ceramides. Dot size corresponds to fold change between OVA and saline group. n = 8–10 mice per group for a representative experiment of two experiments. *p < 0.05 greater in OVA than saline group, crimson red highlighted chain lengths are above the panels.