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. 2021 Feb 25;2:647134. doi: 10.3389/falgy.2021.647134

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Copyright © 2021 Walker, Ferrie, Hoji, Schroeder-Carter, Cohen, Schnaar and Cook-Mills.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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P4rr decreased β-glucosyl ceramides in placenta and fetal liver of allergic mothers. Moms were treated as in Figure 6A and tissues were collected on GD18. Tissue β-glucosyl ceramides (A,B) and β-galactosyl ceramides (Supplementary Figure 12) were separated by column chromatography and then analyzed by mass spectrometry. (A) Placenta. (B) Fetal liver. n = 8–10 mice per group for a representative experiment of two experiments. *p < 0.05 compared to NT, OVA allergic mother, crimson red highlighted chain lengths are above the panels.