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. 2021 Feb 25;2:647134. doi: 10.3389/falgy.2021.647134

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Copyright © 2021 Walker, Ferrie, Hoji, Schroeder-Carter, Cohen, Schnaar and Cook-Mills.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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P4rr decreased lung lavage inflammation and inflammatory mediators in OVA-challenged pups from allergic mothers. (A) Bronchoalveolar lavage (BAL) leukocytes of postnatal day 13 OVA-challenged pups from allergic and saline (non-allergic) control mothers that were non-treated (NT) or treated with P4rr or P4ss. (B) Body weight. (C) Pup blood eosinophil numbers. (D) Pup BAL IL5, (E) Pup BAL CCL11, (F) Pup BAL CCL24 as determined by ELISA. (G) Pup serum anti-OVA IgE as determined by ELISA. n = 8–10 mice per group for a representative experiment of two experiments. *p < 0.05 compared to the pups of the OVA-treated moms and pups of the OVA P4ss treated moms.