Table 3.
Semi-quantitative histopathological analysis of the skin biopsies (0 absent; 1 mild, 2 moderate, 3 profound).
| Treatment Arm | Apoptosis | Mitosis | Micronucleation | Atypia | Inflammation | Ki67 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | CPC634 | Cd | Baseline | CPC634 | Cd | Baseline | CPC634 | Cd | Baseline | CPC634 | Cd | Baseline | CPC634 | Cd | Baseline | CPC634 | Cd | |
| A | 0 | 13 | 3 | 0 | 10 | 0 | 0 | 2 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 1% | 50% | 5% |
| A | 0 | 11 | 3 | 1 | 4 | 4 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 5% | 5% | 5% |
| A | 5 | 97 | 8 | 1 | 31 | 6 | 0 | 3 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 5% | 50% | 25% |
| A | 1 | 9 | 4 | 0 | 7 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 5% | 5% | 5% |
| A | 0 | 21 | 6 | 0 | 5 | 9 | 0 | 1 | 3 | 0 | 0 | 2 | 1 | 1 | 1 | 5% | 5% | 5% |
| A | 0 | 9 | 26 | 0 | 3 | 8 | 0 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 5% | 5% | 50% |
| A | 0 | 7 | NA | 0 | 2 | NA | 0 | 1 | NA | 0 | 1 | NA | 1 | 1 | NA | 5% | 5% | NA |
| B | 0 | 0 | 8 | 0 | 4 | 0 | 0 | 2 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 5% | 5% | 25% |
| B | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 5% | 5% | 5% |
| B | 0 | 12 | 8 | 3 | 3 | 0 | 0 | 2 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 5% | 50% | 5% |
Abbreviations; conventional docetaxel (Cd); not applicable (NA).