Figure 1.

HIF-1α nucleoshuttling is induced by photons under normoxia and hypoxia, but only under hypoxia with C-ions (a) Representative images at 4 h of SQ20B^CD44Low cells (0 or 2 Gy photons and C-ions, under normoxia or hypoxia) are presented with the indicated biomarkers. (b) Signal intensities of HIF-1α into the nucleus were measured for each condition and normalized to basal signal. The means ± SD were statistically compared to the basal ratio. (Student’s t-Tests using Holm–Sidak method, α = 0.5). (n = 3 photons; n = 2 C-ions). * p < 0.05.