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. 2021 Jul 23;13(15):3716. doi: 10.3390/cancers13153716

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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APAs undergo transcriptomic alterations toward increased fatty acid metabolism and glycolysis. (A) GSEA showing MSigDB hallmark of upregulated differentially expressed genes in APAs versus AAC (GSE60042) and adjacent ZG (GSE64957). Pathways in red indicate functions related to lipid metabolism and glycolysis. (B) Heatmap of the significant upregulated differentially expressed genes with p value < 0.05 for fatty acid metabolism in APAs compared with adjacent ZG. (C) GSEA plots showing Reactome pathways of lipid biological processes in APAs versus adjacent ZG. (D) GSEA plots showing Reactome pathways of mitochondrial fatty acid β-oxidation in ZF versus paired adjacent ZG. APA, aldosterone-producing adenoma; AAC, adjacent adrenal cortex; ZG, zona glomerulosa; ZF, zona fasciculata; NES, normalized enrichment score; FDR, false discovery rate.