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. 2021 Jul 23;13(15):3716. doi: 10.3390/cancers13153716

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Spatial organization of tumor infiltrating immune cells in APAs versus paired adjacent adrenal cortex (AAC). (A) GSEA showing MSigDB hallmark of downregulated differentially expressed genes in APAs versus AAC (GSE60042). Pathways in red indicate functions related to immune response. (B) CYP11B2 and CD45 immunohistochemistry staining. The border of APA is defined by the CYP11B2 immunohistochemistry. Scare bar: 100 μm. (C) ESTIMATE algorithm showing the distribution of ImmuneScore, StromalScore in APAs versus AAC. ** p < 0.01 by paired t test. (D) CD45⁺ immune cell density and positive percentage between APAs and AAC. *** p < 0.001 by paired Wilcox test. APA, aldosterone-producing adenoma; AAC, adjacent adrenal cortex; NES, normalized enrichment score.