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Suggested IHC work-up for the differential diagnosis in BCs with mixed-appearing morphology (modified according ref. [61]).
| Diagnosis | Collision BC (NST + ILC) |
Tubulo- Lobular BC |
ILC with Tubular Elements |
|||
|---|---|---|---|---|---|---|
| Component | Dissociated | Tubules | Dissociated | Tubules | Dissociated | Tubules |
| E-cadherin | neg. | pos. | pos. | pos. | neg. | neg. |
| β-catenin | neg. | pos. | pos. | pos. | neg. | pos. |
| P-cadherin | neg. | pos. | ||||
