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. 2021 Jul 24;13(15):3729. doi: 10.3390/cancers13153729

Figure 3.

Figure 3

Dox-elicited mitochondrial dysfunction is rescued in mNVCM pretreated with either hAFS-CM or hMSC-CM. From the top left corner: Oxygen consumption rate stimulated with pyruvate plus malate; ATP production by Fo-F1 ATP synthase stimulated with pyruvate plus malate; mNVCM P/O ratio after pyruvate plus malate stimulation, as a marker of OxPhos efficiency; Glucose consumption; lactate release; lactate fermentation percentage. All the biochemical measurements were performed in mNVCM treated as follows: control condition (Ctrl), after exposure to 1 µM Dox (Dox), pretreated with hAFS-CM or hMSC-CM before the Dox stimulation (hAFS-CM+Dox and hMSC-CM + Dox, respectively), or only pretreated with hAFS-CM or hMSC-CM (HAFS-CM and hMSC-CM, respectively). In each panel, values are expressed as the mean ± SEM of the independent experiments; hAFS-CM vs. Ctrl and hMSC-CM vs. Ctrl # p = 0.0495 or #### p < 0.0001; Ctrl vs. Dox §§§§ p < 0.0001; hAFS-CM + Dox vs. Dox and hMSC-CM + Dox vs. Dox **** p < 0.0001.