Table 1.
Patients’ characteristics at baseline and HPV persistence status at 3–9 months (first follow-up visit) from baseline.
| Characteristic | Level | N (Col %) | HPV Persistence, N (Row %) | p-Value | |
|---|---|---|---|---|---|
| All Patients N = 408 |
Not-Persistent N = 312 |
Persistent N = 96 |
|||
| Age, years | 40 (35–46) a | 39 (35–46) a | 40 (35–46) a | 0.53 | |
| Histology | CIN1 | 72 (17.7) | 59 (81.9) | 13 (18.1) | |
| CIN2/3/AIS | 313 (76.7) | 232 (74.1) | 81 (25.9) | ||
| ICC | 23 (5.6) | 21 (91.3) | 2 (8.7) | 0.09 | |
| Infection status | Single infection | 296 (72.6) | 236 (79.7) | 60 (20.3) | |
| Multiple (≥2) infection | 112 (27.5) | 76 (67.9) | 36 (32.1) | 0.01 | |
| No. of infections b | 1 | 296 (72.6) | 236 (79.7) | 60 (20.3) | |
| 2 | 83 (20.3) | 60 (72.3) | 23 (27.7) | ||
| ≥3 | 29 (7.1) | 16 (55.2) | 13 (44.8) | 0.009 | |
| Ectocervical margin c | Negative | 392 (97.3) | 299 (76.3) | 93 (23.7) | |
| Positive | 11 (2.7) | 9 (81.8) | 2 (18.2) | 1.00 | |
| Endocervical margin c | Negative | 386 (95.8) | 298 (77.2) | 88 (22.8) | |
| Positive | 17 (4.2) | 10 (58.8) | 7 (41.2) | 0.14 | |
| Surgical margins | Negative | 376 (92.2) | 290 (77.1) | 86 (22.9) | |
| Positive | 32 (7.8) | 22 (68.8) | 10 (31.2) | 0.28 | |
| Glandular crypts involvement | No | 192 (47.1) | 149 (77.6) | 43 (22.4) | |
| Yes | 216 (52.9) | 163 (75.5) | 54 (24.5) | 0.64 | |
a Median (IQR), b number of different detected genotypes per patient, c N = 403 (HPV not-persistent N = 308, HPV persistent N = 95). HPV = Human Papillomavirus, CIN = cervical intraepithelial neoplasia, AIS = adenocarcinoma in situ, ICC = invasive cervical carcinoma.