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The combination of IM and MK-4440 inhibits constitutive activation of effectors downstream of KIT. Immunoblot assays of WCEs from GIST-T1 treated with 40 nM IM, 120 nM MK-4440 or the combination; and GIST430 and GIST-T1/829 treated with 1 μM IM, 3 μM MK-4440, or the combination. All treatments were twenty hours in duration. Equal quantities of WCE from each sample were subjected to immunoblotting with specific antibodies, as indicated. GAPDH served as loading control.
