Figure 7.
Proposed mechanism of dual inhibition of KIT and AKT in GIST. Dual inhibition of KIT and AKT in GIST cells leads to decreased activation of pS6, associated PDCD4 upregulation, increased apoptosis and cell cycle arrest.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.