Table 1.
microRNAs associated with tamoxifen-resistance.
| microRNA | Targets | Reference |
|---|---|---|
| Upregulated | ||
| miR-9-5p | ADIPOQ, ESR1, NCOA3 | [111,112] |
| miR-10b | HDAC4 | [56] |
| miR-15b | FOXO1 | [113] |
| miR-18a | ESR1 | [114] |
| miR-21 | PDCD4, TPM1 | [86,115,116,117] |
| miR-22 | ESR1, PTEN | [118] |
| miR-23b-3p | SLC6A14, ZBTB1 | [119,120] |
| miR-24-3p | BIM | [84] |
| miR-92a-3p | C21orf91, GPM6A, KAT2B, NEDD4L, UBE2Z, ROBO2, PCDH11X, PDS5B, TMEM87A, PRKCE | [121] |
| miR-101 | MAGI-2 | [122] |
| miR-140 | -- | [122] |
| miR-155 | SOCS6 | [123] |
| miR-181 | -- | [86] |
| miR-192-5p | ESR1 | [89] |
| miR-221/222 | P27, ESR1, TRPS1 | [86,87,88,93] |
| miR-301 | PTEN, FOXF2, COL2A1, BBC3 | [101] |
| miR-335-3p; miR-335-5p | ESR1 | [90] |
| miR-342 | -- | [124] |
| miR-342-3p; miR-342-5p | NR4A2, MAGED2, LASP1, UCP2, THSD4, PRODH, PIP4KSC, MEIS1, BMP7, PRR6, GEMIN4, GJAI, SEMA3D | [117,124] |
| miR-335-5p, miR-335-3p | ESR1 | [90] |
| miR-380 | -- | [122] |
| miR-489 | -- | [86] |
| miR-497 | -- | [125] |
| miR-519a | CDKN1A, RB1, PTEN | [102,125] |
| miR-542-5p | YWHAB, LY9, SFRP1 | [126] |
| miR-552 | -- | [122] |
| miR-575 | CDKN1B | [127] |
| miR-578 | -- | [122] |
| miR-599 | -- | [122] |
| miR-663b | TP73 | [128] |
| miR-671-3p | HNRNPA2B1 | [129] |
| miR-1266-5p | HNRNPA2B1 | [129] |
| miR-1268a | HNRNPA2B1 | [129] |
| miR-1280 | -- | [125] |
| Downregulated | ||
| let-7 | ESR1 (ER-α36 isoform) | [130] |
| miR-15a | BCL2, CCNE1 | [124,131] |
| miR-16 | BCL2, CCNE1 | [124,131] |
| miR-21 | PTEN, PDCD4 | [132] |
| miR-26a | E2F7, EZH2, ERBB22H1 | [40] |
| miR-27a;miR-27b-3p | HMGB3, NR5A2, CREB1 | [59,107,133] |
| miR-29a;miR-29b-1 | DICER1, PTEN | [104] |
| miR-29a-3p; miR-29b-3p | HNRNPA2B1, ATP5G1, ATPIF1 | [104,129] |
| miR-32-5p | CUL4B | [96] |
| miR-101 | -- | [125] |
| miR-106a | CDKN1A, PTEN, RB1 | [125] |
| miR-125a | CYP4Z1, CYP4Z2P, CDK3, HER2, HER3 | [108,134] |
| miR-125a-3p; miR-125a-5p | HDAC5 | [105,109] |
| miR-125b-5p | PAD2 | [135] |
| miR-135a | ESR1, ESRRA, NCOA1 | [94] |
| miR-146a; miR-146b | NFKB1, PI3K, TRAF6, IRAK1, PTEN | [103,117] |
| miR-148a | ALCAM | [60] |
| miR-152 | ALCAM | [60] |
| miR-181 | -- | [125] |
| miR-186-3p | EREG | [110] |
| miR-193a/b-3p | ESR1, NCOA3 | [112] |
| miR-196a | HOXB7 | [136] |
| miR-200 | ZEB1/2 | [137] |
| miR-214 | UCP2 | [58] |
| miR-222-3p | ESR1, CDKN1B, HNRNPA2B1 | [129] |
| miR-320a | ARPP19, ESRRG | [106] |
| miR-342 | TXNIP, SEMAD, BMP7, GEMIN4 | [138] |
| miR-363 | SERTAD3 | [139] |
| miR-375 | HOXB3, MTDH | [102,140] |
| miR-378a-3p | GOLT1A | [141] |
| miR-449a | ADAM22 | [142] |
| miR-451 | 14-3-3ζ | [143,144] |
| miR-484 | KLF4 | [145] |
| miR-500a-3p | LY6K | [89] |
| miR-574-3p | CLTC | [134] |
| miR-873 | CDK3 | [57,146] |
| miR-877 | -- | [134] |
| miR-4653-3p | FRS2 | [108] |
Note: Regulation (up or down) of miRNAs in tamoxifen resistant breast cancer cells is indicated as reported. (--) information not provided in the study.