Table 2.
Univariate and multivariable analysis of cancer-specific survival in intrahepatic cholangiocarcinoma. Various parameters are associated with cancer-specific survival. ALT, alanine aminotransferase; ASA, American society of anesthesiologists classification; AST, aspartate aminotransferase; BMI, body mass index; GGT, gamma glutamyltransferase; INR, international normalized ratio; LVI, lympho-vascular invasion; MVI, microvascular invasion; NF, nerve fibers; PNI, perineural invasion.
| Univariate Analysis | Multivariable Analysis | |||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Demographics | ||||
| Sex (male = 1) | 0.76 (0.45–1.27) | 0.297 | ||
| Age (≤65 years = 1) | 1.30 (0.77–2.15) | 0.330 | ||
| BMI (≤25 kg/m2 = 1) | 1.17 (0.67–1.96) | 0.549 | ||
| ASA (I/II = 1) | 1.31 (0.79–2.19) | 0.299 | ||
| Clinical chemistry | ||||
| Albumin (≤45 g/L = 1) | 0.86 (0.52–1.43) | 0.560 | ||
| AST (≤35 U/L = 1) | 1.15 (0.69–1.93) | 0.588 | ||
| ALT (≤30 U/L = 1) | 1.38 (0.82–2.35) | 0.228 | ||
| GGT (≤120 U/L = 1) | 1.39 (0.83–2.34) | 0.214 | ||
| Bilirubin (≤0.5 mg/dL = 1) | 1.53 (0.91–2.57) | 0.105 | ||
| Alkaline phosphatase (≤115 U/L = 1) |
1.69 (0.99–2.89) | 0.054 | excluded | |
| Platelet count (≤250/nL = 1) | 0.82 (0.49–1.37) | 0.445 | ||
| INR (≤1 = 1) | 1.54 (0.91–2.61) | 0.107 | ||
| Hemoglobin (≤13 g/dL = 1) | 0.61 (0.37–1.03) | 0.063 | 0.51 (0.27–0.93) | 0.024 |
| Operative data | ||||
| Operative time (≤300 min = 1) | 1.11 (0.68–1.80) | 0.682 | ||
| Type of hepatectomy | 0.935 | |||
| Right/left hepatectomy | 1 | |||
| Others | 0.92 (0.541–1.62) | |||
| Blood transfusion (no = 1) | 1.52 (0.91–2.57) | 0.113 | ||
| Postoperative data | ||||
| Clavien–Dindo Score (CD I/II = 1) |
2.05 (1.22–3.47) | 0.007 | exlcuded | |
| Intensive care (≤1 day = 1) | 1.49 (0.85–2.62) | 0.168 | ||
| Hospitalization (≤13 days = 1) | 1.52 (0.91–2.54) | 0.106 | ||
| Pathological data | ||||
| R1 resection (no = 1) | 1.58 (0.63–3.96) | 0.329 | ||
| pT category (T1/T2 = 1) | 1.49 (0.81–2.77) | 0.203 | ||
| pN category (N0 = 1) | 4.32 (2.48–7.52) | 0.001 | 4.78 (2.54–9.01) | 0.001 |
| Tumor grading (G1/G2 = 1) | 2.13 (1.16–3.89) | 0.014 | excluded | |
| MVI (no = 1) | 1.59 (0.95–2.68) | 0.078 | excluded | |
| LVI (no = 1) | 3.60 (1.92–6.76) | 0.001 | excluded | |
| PNI (no = 1) | 2.49 (1.23–5.01) | 0.011 | ||
| NF (no = 1) | 0.58 (0.34–0.99) | 0.048 | 0.47 (0.24–0.90) | 0.024 |
| Oncological data | ||||
| Neoadjuvant therapy (no = 1) | 2.18 (0.87–5.50) | 0.098 | 8.84 (2.20–35.49) | 0.002 |
| Adjuvant therapy (no = 1) | 1.17 (0.67–2.04) | 0.587 | ||