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. 2021 Jul 29;13(15):3821. doi: 10.3390/cancers13153821

Figure 2.

Figure 2

ZIP4 upregulated Class IIa HDACs. (A,B). ZIP4-OE up regulated the expression of HDAC4, 5, and 7; ZIP4-KO and NOTCH3-KO downregulated the expression HDAC4, 5, and 7 in PE04 cells, with little or no effect on other classes of HDACs. (C). Summary of quantified Western blot results from > three independent experiments for ZIP4, HDAC4, 5, and 7. (D). PEA2 cells expressed relatively higher levels of HDAC4, 5, and 7 than PEA1 cells; ZIP4-KD reduced expression levels of HDAC4, 5, and 7 in PEA2 cells. (E). Summary of quantified Western analyses results from > three independent experiments. * p < 0.05; ** p < 0, 01; *** p < 0.001.