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. 2021 Jul 28;13(15):3806. doi: 10.3390/cancers13153806

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Complement-related mechanisms associated with ovarian cancer progression. Complement components have been implicated in different biological processes associated with ovarian cancer progression. They include modulation of immunosuppression in the tumor microenvironment; regulation of angiogenesis and endothelial permeabilization; autocrine and paracrine effects in tumor cells mediated by C1q, C3a, or C5a; and inhibition of complement-dependent cytotoxicity (CDC) by membrane-bound complement regulators.