Figure 10.
Relationship between anhedonia and ACC GABA levels in adolescents, measured by 1H MRS (standardized vs. water peak). (A) When depressed subjects were stratified into anhedonic (n = 19) and non-anhedonic (n = 25) subgroups, only anhedonic subjects differed significantly from healthy controls (n = 36). (B) Within the combined sample of depressed adolescents (N = 44), anhedonia was negatively associated with ACC GABA after controlling for depression severity (partial r = −0.33, p = 0.03). Excerpted from (170). *Significant at the Šidák-corrected p < 0.05 level.