Table 2.
Cox proportional hazard ratios. Estimated coefficients of relapse-free survival on breast cancer subjects. Calculated are the corresponding hazard ratio (HR), 95% confidence interval (CI) of the hazard ratio, and p-value in uni- and multivariable Cox proportional hazard analysis for the presence of K16-positive CTCs, estrogen receptor (ER) status, progesterone receptor (PR) status, ERBB2 status, and T-stage (reference T1-2).
| Univariable Analysis | Multivariable Analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Covariate | Coefficient (bi) | HR [exp(bi)] | HR 95% CI | p-Value | Coefficient (bi) | HR [exp(bi)] | HR 95% CI | p-Value |
| K16+ CTCs | 2.061 | 7.856 | (1.677, 36.81) | 0.0089 | 4.864 | 129.6 | (1.6, 1.120) | 0.0287 |
| Age | −0.072 | 0.930 | (0.867, 0.998) | 0.0432 | −0.217 | 0.804 | (0.627, 1.032) | 0.0869 |
| ER+ | −0.638 | 0.528 | (0.166, 1.680) | 0.280 | −5.909 | 0.003 | (0.0, 0.951) | 0.0481 |
| PR+ | −0.150 | 0.861 | (0.275, 2.693) | 0.797 | 3.857 | 47.3 | (0.108, 2.670) | 0.2136 |
| ERBB2+ | 0.078 | 1.081 | (0.283, 4.123) | 0.910 | −0.435 | 0.647 | (0.030, 14.1) | 0.7820 |
| T3-4 | 0.272 | 1.312 | (0.286, 6.420) | 0.737 | 0.117 | 1.352 | (0.080, 15.9) | 0.9308 |
CTCs = circulating tumor cells, ER = estrogen receptor, PR = progesterone receptor, ERBB2 = Erb-B2 Receptor Tyrosine Kinase 2, HR = hazard ratio.