Table 4.
Hazard ratios and 95% confidence intervals of cancer incidence associated with mtDNA-CN (n = 2888) and relative telomere length (n = 3037).
| Characteristics | MtDNA-CN | HR (95% CI) per 1-SD Decrease in mtDNA-CN |
Relative Telomere Length | HR (95% CI) per 1-SD Decrease in Telomere Length |
p for Interaction c | ||
|---|---|---|---|---|---|---|---|
| High (n = 1406) | Low (n = 1482) | Long (n = 1473) | Short (n = 1564) | ||||
| All cancer | |||||||
| No. of cancer diagnoses | 242 | 249 | 256 | 264 | |||
| Person-years of follow-up | 21,700 | 22,238 | 23,394 | 22,626 | |||
| IR, per 1000 person-years | 11.15 | 11.19 | 10.94 | 11.67 | |||
| Crude HR (95% CI) | 1 (Ref) | 1.04 (0.87–1.24) | 1.01 (0.92–1.10) | 1 (Ref) | 0.97 (0.82–1.16) | 1.02 (0.94–1.11) | |
| Adjusted HR (95% CI) a | 1 (Ref) | 0.99 (0.83–1.19) | 0.99 (0.90–1.08) | 1 (Ref) | 0.93 (0.78–1.10) | 1.00 (0.92–1.09) | 0.607 |
|
Cancer types (adjusted HR and 95% CI a) |
|||||||
| Breast cancer | 1 (Ref) | 1.05 (0.78–1.42) | 0.95 (0.84–1.08) | 1 (Ref) | 1.03 (0.77–1.38) | 0.98 (0.84–1.14) | 0.197 |
| Digestive system | 1 (Ref) | 0.83 (0.54–1.29) | 1.03 (0.84–1.26) | 1 (Ref) | 1.11 (0.71–1.72) | 1.05 (0.88–1.25) | 0.225 |
| Respiratory system | 1 (Ref) | 0.91 (0.42–2.02) | 1.18 (0.88–1.60) | 1 (Ref) | 0.58 (0.29–1.16) | 0.83 (0.63–1.10) | 0.192 |
| Genital organs | 1 (Ref) | 0.60 (0.33–1.10) | 0.84 (0.72–0.98) b | 1 (Ref) | 1.16 (0.66–2.05) | 1.13 (0.87–1.47) | 0.207 |
| Urinary system | 1 (Ref) | 8.20 (1.06–63.2) b | 1.08 (0.72–1.63) | 1 (Ref) | 1.35 (0.45–4.08) | 1.79 (1.05–3.07) b | <0.001 |
| Hematological cancer | 1 (Ref) | 1.97 (1.02–3.81) b | 1.11 (0.85–1.46) | 1 (Ref) | 0.81 (0.43–1.54) | 0.97 (0.71–1.32) | 0.007 |
| Nervous system | 1 (Ref) | 1.62 (0.49–5.31) | 1.07 (0.66–1.72) | 1 (Ref) | 0.68 (0.22–2.07) | 0.74 (0.45–1.22) | 0.314 |
| Skin | 1 (Ref) | 0.82 (0.49–1.39) | 1.05 (0.82–1.34) | 1 (Ref) | 0.81 (0.50–1.32) | 1.11 (0.88–1.38) | 0.171 |
| Endocrine glands | 1 (Ref) | 0.79 (0.29–2.13) | 1.01 (0.63–1.63) | 1 (Ref) | 0.67 (0.27–1.69) | 0.76 (0.49–1.16) | 0.331 |
a Adjusted for age, BMI, education level, smoking habits, alcohol consumption, activity at work, activity at home, diabetes, CVD, hypertension. b p < 0.05. c Interactions were calculated by inclusion of interaction terms. IR, incidence rate.