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. 2021 Jul 31;13(15):3871. doi: 10.3390/cancers13153871

Figure 3.

Figure 3

NK1R Antagonism decreased cisplatin-induced ROS in rat neuronal PC12 cells while causing increased cisplatin-induced ROS levels in TNBC cells. Effect of NK1R antagonism on ROS Production induced by cisplatin in PC12 cells and TNBC cells. Levels of ROS as determined by the DCFDA assay, in untreated (media control) or treated with aprepitant or cisplatin alone or cisplatin + aprepitant, in PC12 (A), Sum 185 (B,C), Sum 159 cells (*, †, ‡, p ≤ 0.05, ANOVA, n = 2). Only statistical comparisons between control vs. aprepitant (AP) or Cis and Cis vs. Cis + AP are shown.