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. 2021 Jul 31;13(15):3871. doi: 10.3390/cancers13153871

Figure 4.

Figure 4

NK1R Antagonism protects PC12 cells while causing enhancement of cisplatin-induced apoptosis in TNBC cells. PC12, Sum 185 and Sum 159 TNBC cells were untreated (media control) or treated with aprepitant or cisplatin alone or cisplatin + aprepitant, stained with Annexin V-FITC/PI and cell apoptosis analyzed by flow cytometry (A,C,E). Quadrant gating was made based on unstained controls. Q2 demonstrates necrotic cells, Q3 demonstrates apoptotic cells, and Q4 demonstrates viable cells. Levels of apoptosis (% positive) in the different groups in PC12 (B), Sum 185 (D) and Sum 159 cells (F) (*, †, ‡, p ≤ 0.05, ANOVA, n = 2). Only statistical comparisons between control vs. AP or Cis and Cis vs. Cis + AP are shown.