Table 4.

Lead times with 95% confidence intervals (95% CI) calculated from first timepoint of elevated marker to radiological or clinical diagnosis of local relapse or metastatic disease.

	n	Median (Months)	95% CI
CEA elevated	29	7.8	5.7–9.8
CA19-9 elevated	14	10.0	6.7–13.3
IL-6 elevated	16	21.8	4.0–39.6
CRP elevated	12	10.2	5.4–15.1
YKL-40 elevated	27	53.1	27.1–79.1
CEA, CA19-9, IL-6, CRP, or YKL-40 elevated	42	27.3	17.1–37.5