Table 2.

Top 20 proteins of machine learning analysis.

Rank	Benign vs. ACC						Stage 1–2 vs. 3–4						Stage 1–3 vs. 4
	InfoGain		ANOVA		ReliefF		InfoGain		ANOVA		ReliefF		InfoGain		ANOVA		ReliefF
	Gene Name	Score	Gene Name	Score	Gene Name	Score	Gene Name	Score	Gene Name	Score	Gene Name	Score	Gene Name	Score	Gene Name	Score	Gene Name	Score
1	H2AFY2	0.787	PDE4D	62.944	MUSTN1	0.321	EPG5	0.681	EPG5	24.961	NUDC	0.239	WBSCR16	0.658	WBSCR16	52.070	WBSCR16	0.303
2	ABLIM1	0.654	SYNE1	60.441	ARMC8	0.298	GNPAT	0.531	NUDC	24.001	GNPAT	0.226	CCDC12	0.658	CCDC12	31.394	NOSIP	0.234
3	DNPH1	0.654	H2AFY2	60.114	SNX15	0.296	DECR2	0.531	GNPAT	23.111	FAM160B2	0.217	PDHA1	0.658	PDHA1	31.002	CCDC12	0.196
4	ACIN1	0.531	MUSTN1	53.536	SYNE1	0.291	PPIF	0.531	STRIP1	22.252	SNX8	0.191	LYRM1	0.581	PDHB	28.034	GHITM	0.188
5	RPS24	0.531	ARMC8	48.449	PDE4D	0.276	SPR	0.531	A1BG	21.073	NGEF	0.182	RRM2	0.581	RBM26	24.492	MRPL32	0.184
6	FUBP3	0.526	CAB39L	44.931	CAB39L	0.275	SLC25A32	0.531	NDUFAF2	20.221	CTSA	0.170	NCEH1	0.519	MTIF2	21.829	PDHB	0.179
7	SYNE1	0.526	PPM1G	42.526	RALGAPB	0.270	COG3	0.531	CHMP6	19.245	A1BG	0.166	ARSA	0.519	CSNK1D	21.478	SNCG	0.171
8	ARMC8	0.526	MTA2	41.666	SNRNP70	0.251	ISOC1	0.531	SNX8	18.413	ATM	0.164	CAV1	0.519	SNCG	20.043	PDHA1	0.170
9	HSD17B13	0.526	SLC37A2	40.937	AAR2	0.245	TTC1	0.522	ALDH3B1	17.218	PTK2B	0.163	RABL3	0.519	LYRM1	19.369	RBM26	0.167
10	PDE4D	0.526	UBE2M	39.877	MZB1	0.239	MRPS5	0.522	CTSA	17.069	STRIP1	0.160	MRPS23	0.510	NCEH1	17.250	NCEH1	0.153
11	UBE2M	0.526	DNPH1	39.713	H2AFY2	0.237	AGRN	0.478	TTC1	17.034	CHMP6	0.158	TPBG	0.499	NOSIP	17.024	PNMA3	0.152
12	SKIV2L2	0.526	XPOT	38.513	NIFK	0.230	FBLN2	0.478	HADH	17.000	MMTAG2	0.157	PDHB	0.475	NMNAT1	16.105	LYRM1	0.146
13	SHMT2	0.526	NIFK	36.911	ALG14	0.225	CDK5RAP2	0.478	CMSS1	16.775	DNAJC15	0.156	MAPK9	0.475	COL4A2	15.781	NID2	0.142
14	CPB1	0.526	SCCPDH	36.042	CPB1	0.220	A1BG	0.458	APOC1	16.197	EPG5	0.153	MTIF2	0.475	MTHFD2L	15.740	RABAC1	0.140
15	XPOT	0.526	SKIV2L2	35.957	WNT2B	0.210	C8G	0.458	PPIF	16.157	TTC1	0.153	NMNAT1	0.475	POLDIP2	15.577	C9orf91	0.138
16	HNRNPA1	0.526	HNRNPA1	35.727	SCCPDH	0.201	LTBP4	0.458	PCNT	15.578	SERPINA3	0.151	MRPL22	0.475	MAPK9	15.468	MTHFD2L	0.138
17	CSNK2A1	0.526	VCPIP1	35.452	PPM1G	0.200	C8A	0.458	SERPINA3	15.499	IGHV4-34	0.146	LDB3	0.475	NID2	15.440	MAPK9	0.137
18	MUSTN1	0.526	RPL24	35.172	RPL24	0.199	NUDC	0.396	SERPINC1	15.308	CSDC2	0.144	ALOX5	0.475	BLOC1S3	15.217	MRPL1	0.137
19	PPIH	0.526	FBXW8	34.574	UBQLN4	0.198	PTK2B	0.396	PTK2B	15.098	ELOVL5	0.144	COL4A2	0.431	PPOX	15.193	LACC1	0.136
20	RAN	0.526	SRXN1	32.834	INPP1	0.196	ALDH3B1	0.396	TGFB1	15.072	SLC9A3R2	0.142	GHITM	0.427	PLOD2	15.117	PEX3	0.135

ACC—adrenal cortical carcinoma; ANOVA—analysis of variance; InfoGain—Information Gain.