Table 3.
C-index and net reclassification index.
| Variables | SNUH Cohort | TCGA Cohort | ||||
|---|---|---|---|---|---|---|
| C-Index (95% CI) | NRI (95% CI) | p-Value for NRI | C-Index (95% CI) | NRI (95% CI) | p-Value for NRI | |
| Age+Stage | 0.690 (0.551—0.829) | - | - | 0.674 (0.552—0.796) | - | - |
| Age+Stage+HNRNPA1 | 0.704 (0.563—0.845) | 0.813 (0.225—1.401) | 0.007 | 0.757 (0.662—0.852) | 0.625 (0.179—1.070) | 0.006 |
| Age+Stage C8A | 0.727 (0.612—0.841) | 0.152 (−0.480—0.784) | 0.637 | 0.674 (0.550—0.798) | 0.228 (−0.070—0.526) | 0.134 |
| Age+Stage+CHMP6 | 0.756 (0.645—0.867) | 0.152 (−0.480—0.784) | 0.637 | 0.683 (0.568—0.797) | −0.234 (−0.704—0.236) | 0.329 |
| Age+Stage+LTBP4 | 0.702 (0.561—0.842) | 0.596 (−0.018—1.211) | 0.057 | 0.752 (0.639—0.865) | 0.585 (0.138—1.031) | 0.010 |
| Age+Stage+SPR | 0.718 (0.583—0.852) | 0.503 (−0.088—1.094) | 0.095 | 0.681 (0.559—0.803) | 0.311 (−0.154—0.776) | 0.190 |
| Age+Stage+NCEH1 | 0.695 (0.550—0.839) | 0.485 (−0.140—1.111) | 0.128 | 0.689 (0.575—0.803) | 0.428 (−0.030—0.885) | 0.067 |
| Age+Stage+MRPS23 | 0.740 (0.618—0.862) | 0.819 (0.239—1.398) | 0.006 | 0.729 (0.632—0.825) | 0.508 (0.052—0.963) | 0.029 |
| Age+Stage+POLDIP2 | 0.733 (0.612—0.855) | 0.591 (−0.024—1.205) | 0.060 | 0.741 (0.666—0.816) | 0.508 (0.052—0.963) | 0.029 |
| Age+Stage+WBSCR16 | 0.740 (0.606—0.874) | 0.702 (0.098—1.305) | 0.023 | 0.743 (0.668—0.818) | 0.508 (0.052—0.963) | 0.029 |
| Age+Stage+HNRNPA1+MRPS23+WBSCR16 a | 0.708 (0.579—0.838) | 0.175 (−0.447—0.797) | 0.58 | 0.752 (0.659—0.845) | 0.492 (0.091—0.894) | 0.016 |
Age per 10 years and stage of 1–2 vs. 3 vs. 4 is used. HNRNPA1, C8A, CHMP6, LTBP4, and NCEH1 were analyzed as high versus low expressions, and SPR, MRPS23, POLDIP2, and WBSCR16 were analyzed as high versus low expressions; a The analysis compared patients with high HNRNPA1, low MRPS23 and WBSCR16, and those who did not. Values in bold in the p-value indicate statistical significance. C8A—complement C8 alpha chain; CHMP6—charged multivesicular body protein 6; C-index—concordance index; CI—confidence interval; HNRNPA1—heterogeneous nuclear ribonucleo-protein A1; LTBP4—latent transforming growth factor beta binding protein 4; MRPS23—mitochondrial ribosomal protein S23; NCEH1—neutral cholesterol ester hydrolase 1; NRI—net reclassification improvement; POLDIP2—polymerase delta-interacting protein 2; SNUH—Seoul National University Hospital; SPR—sepiapterin reductase; TCGA—The Cancer Genome Atlas; WBSCR16—Williams-Beuren syndrome chromosome region 16.