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. 2021 Jun 22;251(1):1–13. doi: 10.1530/JOE-20-0617

Table 3.

Fatty acid profile in plasma and brain of 3 months old offspring.

Fatty acids (g/100 g fatty acids) GDM (n = 16) GDM+ADI (n = 14) Control (n = 11) P
 16:0 22.74 ± 0.56 22.58 ± 0.65 20.75 ± 0.77 0.383
 18:0 13.77 ± 0.63 15.54 ± 0.78 15.82 ± 0.79 0.528
 18:1 n-9 9.16 ± 0.43a 5.95 ± 0.33b 10.63 ± 0.53c <0.001
 18:2 n-6 15.36 ± 0.77 12.02 ± 0.71 11.80 ± 1.01 0.184
 20:4 n-6 29.87 ± 1.02a 29.81 ± 0.70ab 27.47 ± 1.33b 0.045
 SFA 38.60 ± 0.52a 43.04 ± 0.82b 39.93 ± 0.66ab 0.007
 MUFA 12.47 ± 0.66a 9.38 ± 0.47a 15.45 ± 0.86b <0.001
 PUFA 48.92 ± 0.60a 47.53 ± 0.62a 44.61 ± 1.45b 0.001
 LC-PUFA n-6 30.00 ± 0.98ab 30.97 ± 0.71a 28.09 ± 1.25b 0.038
 LC-PUFA n-3 3.20 ± 0.19 3.67 ± 0.18 4.27 ± 0.39 0.110
Brain
 16:0 17.69 ± 0.14 17.91 ± 0.11 17.79 ± 0.12 0.464
 18:0 19.38 ± 0.08 19.87 ± 0.17 19.66 ± 0.10 0.150
 18:1 n-9 16.04 ± 0.17 15.79 ± 0.12 16.34 ± 0.10 0.119
 18:2 n-6 0.72 ± 0.02 0.70 ± 0.02 0.72 ± 0.02 0.819
 20:4 n-6 10.63 ± 0.11 10.56 ± 0.07 10.56 ± 0.11 0.973
 22:6 n-3 (DHA) 17.18 ± 0.17 17.36 ± 0.15 17.15 ± 0.16 0.694
 SFA 40.27 ± 0.13b 41.17 ± 0.23a 40.70 ± 0.12ab 0.037
 MUFA 25.21 ± 0.31 24.22 ± 0.24 24.79 ± 0.31 0.120
 PUFA 34.42 ± 0.22 34.55 ± 0.17 34.36 ± 0.20 0.596
 n-6/n-3 0.90 ± 0.01 0.87 ± 0.01 0.90 ± 0.01 0.337
 LC-PUFA n-6 15.50 ± 0.14 15.38 ± 0.11 15.50 ± 0.14 0.820
 LC-PUFA n-3 17.47 ± 0.16 17.67 ± 0.15 17.44 ± 0.16 0.623

Results are expressed as means ± s.e.m. 3 months old offspring from 3 to 4 pregnant rats per group. Only selected fatty acids are listed but all fatty acids analysed were considered for the calculation of percentages. GDM n = 16 (8 males/8 females), GDM + ADI n = 14 (6 males/8 females), Control n = 11 (6 males/5 females).

Different superscript letters indicate significant differences between experimental groups (P < 0.05) (bold face).

DHA, docosahexaenoic acid; GDM, gestational diabetes mellitus; GDM + ADI, animals with gestational diabetes mellitus treated with AdipoRon; LC-PUFA, long-chain polyunsaturated fatty acids (>18 carbons); MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids; SFA, saturated fatty acids.