Table 3.
Multivariable binary logistic regression analysis (A) and multivariable linear regression analysis (B) of cohort I investigating factors associated with NAFLD in different BMI strata compared with lean patients (BMI <25 kg/m2) without NAFLD
| Lean w/o NAFLD | Lean NAFLD | Overweight NAFLD | Obese NAFLD | |
| A | ||||
| Metabolic syndromea | Reference | 4.27 (2.80 to 6.51), P < 0.001 | 11.38 (8.29–15.62), P < 0.001 | 42.59 (29.90–60.66), P < 0.001 |
| Hypertension | Reference | 1.06 (0.73 to 1.52), P = 0.775 | 1.91 (1.37–2.65), P < 0.001 | 3.04 (1.83–5.04), P < 0.001 |
| Dyslipidemia | Reference | 2.22 (1.55 to 3.19), P < 0.001 | 2.83 (2.08–3.84), P < 0.001 | 3.44 (2.22–5.31), P < 0.001 |
| Dysglycemia | Reference | 1.57 (1.08 to 2.27), P = 0.017 | 1.95 (1.41–2.68), P < 0.001 | 1.86 (1.16–2.98), P = 0.010 |
| Prediabetesb | Reference | 1.52 (1.04 to 2.22), P = 0.032 | 1.89 (1.36–2.64), P < 0.001 | 1.57 (0.96–2.57), P = 0.070 |
| DM | Reference | 1.51 (0.86 to 2.67), P = 0.150 | 1.72 (1.10–2.69), P = 0.017 | 2.18 (1.23–3.88), P = 0.008 |
| B | ||||
| OGTT >2 hrb | Reference | 4.80 (0.07 to 9.52), P = 0.047 | 3.97 (1.64–6.29), P = 0.001 | 2.72 (0.48–4.95), P = 0.017 |
| HOMA-IRb | Reference | 0.27 (−0.09 to 0.61), P = 0.149 | 0.36 (0.21–0.50), P = 0.001 | 0.50 (0.31–0.68), P < 0.001 |
| Framingham risk score | Reference | 1.93 (0.95 to 2.92), P < 0.001 | 1.41 (0.90–1.93), P < 0.001 | 1.25 (0.74–1.77), P < 0.001 |
Analyses were adjusted for age, sex, and waist circumference. Displayed values are adjusted odds ratios and adjusted regression coefficient B with 95% confidence intervals.
BMI, body mass index; FBG, fasting blood glucose; DM, diabetes mellitus; HOMA-IR, Homeostasis Model of Insulin Resistance; NAFLD, nonalcoholic fatty liver disease; OGTT, oral glucose tolerance test.
Analysis was not adjusted for waist circumference because this parameter is part of the definition of the metabolic syndrome.
Patients with DM were excluded from the calculation.