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. 2021 Jul 1;12(7):e00377. doi: 10.14309/ctg.0000000000000377

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© 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 6. — Combined use of cisplatin (DDP) and PFK15 is more efficient in inhibiting xenograft tumor growth than single treatment. PFK15 treatment could significantly reduce ATP content in cells. All data are shown as mean ± SD, *P < 0.05; **P < 0.01; (a). Combined use of PFK15 could significantly enhance the apoptosis of AGS cells induced by DDP. All data are shown as mean ± SD, *P < 0.05; **P < 0.01 (b). Representative images of the tumors isolated from the mice. 1#–4#, Ctrl; 5#–7#, PFK15 treatment group; 8#–10#, DDP treatment group; 11#–13#, DDP/PPK15 combined treatment group (c). The weight of the tumors from nude mice. All the data were shown as mean ± SD, *P < 0.05; **P < 0.01; ***P < 0.001 (d). The volume of the tumors from nude mice. All the data were shown as mean ± SD, *P < 0.05; **P < 0.01; ***P < 0.001 (e). The same experiment was performed 2 times with similar results. n.s., no significant.