Table 1.

TGF-β/Smad3-dependent miRNAs and lncRNAs with validated roles in DN.

miRNA/lncRNA	ND Model	Target Gene and Reference
Pathogenic and upregulated
miR-21	db/db mice	Smad7 [101]
miR-192	STZ-induced DN db/db mice	Col1a2 via directly targeting SIP1 [102,103]
miR-377	STZ-induced DN diabetic NOD mice	unclear [104,105]
miR-29a	STZ-induced DN	Col4a1 and Col4a2 [106,107]
miR-29b	db/db mice	Tgfbr1 [108,109]
Erbb4-IR	db/db mice	miR-9b, Smad7 [110,111]
lncRNA9884	db/db mice	MCP-1 [112]
Renoprotective and downregulated
miR-200a	STZ-induced DN	Tgfb2 [113]
let-7b	STZ-induced DN	Tgfbr1, Col1a2, Col4a1 [114,115]