Table 3.

Earliest time for manifestations in MPS I and MPS II mice.

	MPS I	MPS II
Behavior (hypoactivity)	2–4 months [182,183]	6–10 months [160,164,166,168]
Zygomatic arch width	Increased at 4 weeks [184]	Increased at 2–3 months [164,185]
Hearing loss	2 months [186]	17 weeks [163]
Elevated GAG levels in urine and tissue	4 weeks [173,184,187]	4–6 weeks [162,164,165,167,185]