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. 2021 Jul 21;22(15):7782. doi: 10.3390/ijms22157782

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Depletion of PML impairs phosphorylation of CHK1 in response to DNA damage. (A) Phosphorylation of CHK1 in U2OS and HeLa cells treated with siPML in the absence or presence of 1 μM MMC. (B) U2OS cells treated with CHK1 siRNA were immunostained by anti-FANCD2 or anti-FANCA antibody in the absence or presence of 1 μM MMC exposure. Representative immunofluorescence images and their quantification are shown. Over 37 nuclei were counted for statistics. Data represent the mean ± SD from three independent experiments (** p < 0.01; * p < 0.05).