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. 2021 Jul 21;22(15):7782. doi: 10.3390/ijms22157782

Figure 6.

Figure 6

Depletion of CHK1 results in enhanced sensitivity to MMC, which induces ICLs. (A) Sensitivity of MMC was determined by clonogenic assay in HeLa cells treated with siControl or siCHK1. Fixed number of cells were seeded and after 24 h of MMC treatment at the final concentration of 0 to 100 nM. After one week, the colonies were stained by ultraviolet solution. (B) Chemotherapeutic efficacy of HeLa cells treated with 100 nM AZD7762 after 24 h of treatment with indicated concentration of MMC. After one week, the colonies were stained by ultraviolet solution.