Table 2.

Association of clinico-pathological characteristics with ZNF677 expression in PTC.

Clinico-Pathological Characteristics	Total		ZNF677 Loss		ZNF677 Normal		p Value
	No.	%	No.	%	No.	%
No. of patients	1235		168	13.6	1067	86.4
Age (years)
<55	1005	81.4	136	13.5	869	86.5	0.8795
≥55	230	18.6	32	13.9	198	86.1
Sex
Female	938	75.9	122	13.0	816	87.0	0.2829
Male	297	24.1	46	15.5	251	84.5
Extrathyroidal extension
Absent	640	51.8	67	10.5	573	89.5	0.0008 *
Present	595	48.2	101	17.0	494	83.0
pT
pT1	318	26.7	34	10.7	284	89.3	0.2812
pT2	250	21.0	40	16.0	210	84.0
pT3	517	43.5	70	13.5	447	86.5
pT4	105	8.8	16	15.2	89	84.8
pN
pN0	467	42.5	67	14.4	400	85.6	0.5560
pN1	633	57.5	83	13.1	550	86.9
pM
pM0	1091	93.8	142	13.0	949	87.0	<0.0001 *
pM1	72	6.2	24	33.3	48	66.7
Stage
I	1001	83.4	134	13.4	867	86.6	0.0431 *
II	135	11.2	20	14.8	115	85.2
III	20	1.7	3	15.0	17	85.0
IVA	17	1.4	0	0.0	17	100.0
IVB	27	2.3	8	29.6	19	70.4
Histology Type
Classical Variant	850	68.8	113	13.3	737	86.7	<0.0001 *
Follicular Variant	194	15.7	43	22.2	151	77.8
Tall-Cell Variant	106	8.6	5	4.7	101	95.3
Other variants	85	6.9	7	8.2	78	81.8
phospho-AKT IHC
High	499	40.4	116	23.3	383	76.7	<0.0001 *
Low	736	59.6	52	7.1	684	92.9
Metastasis Free Survival
5 years				89.2		95.1	0.0090 *

*—significant p value.