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. 2021 Jul 23;12:666502. doi: 10.3389/fphar.2021.666502

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Copyright © 2021 El Sayed, Kandil and Ghoneum.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PFT alleviated STZ-induced inflammatory changes. Each bar with vertical line represents the mean ± SD of three mice per group for TLR4 and of six mice per group for p-NF-kB, TNF-α, IL6, and NLRP3; ^*significantly different from the sham control group at p < 0.05, ^**significantly different from the sham control group at p < 0.01, ^***significantly different from the sham control group at p < 0.001, ^****significantly different from the sham control group at p < 0.0001, ^###significantly different from the STZ group at p < 0.001, ^####significantly different from the STZ group at p < 0.0001 using One-Way ANOVA followed by Tukey’s multiple comparisons test.