FIGURE 7.

Histological sections of H and E staining in the cerebral cortex and hippocampus of the experimental groups; where sham control mouse showed normal histology of neurons in the cerebral cortex (A), and the hippocampus (B). STZ model group brain showed area of malacia associated with focal gliosis and necrosis (C), thickened blood vessel wall (arrow) (E), and perivascular lymphocytic cuffing with surrounding dark degenerated neurons in the cerebral cortex (G), beside neuronal edema of CA1 and CA2 regions (D), as well as neuronal edema of DG region (F) and shrunken dark degenerated neuron in CA3 of the hippocampus (H). Mice receiving pioglitazone showed apparently normal neurons in the cerebral cortex (I) and apparently normal nerve cells in most of the hippocampus regions (J) with few scattered dark degenerated neurons in CA3 and CA4 regions (K). PFT (100 mg/kg) brain revealed variable number of dark degenerated neurons accompanied by gliosis in the cerebral cortex (L) along with neuronal degeneration and neuronophagia with mild thickening of blood vessel wall (M), besides, dark degenerated neurons in the CA4 region (N), and in the DG region of the hippocampus (O). Brain of PFT (200 mg/kg) apparently normal neurons in the cerebral cortex (P), and apparently normal neurons in the hippocampus with few scattered neurons in CA4 and DG (Q). Brain of PFT (400 mg/kg) displayed apparently normal neurons cerebral cortex (R), and apparently normal neurons in the hippocampus (S).